Greater Manchester Police said officers were called to reports of a house fire on Rectory Lane just after 7pm.
Emergency services attended and a man was taken to hospital, where he later died of his injuries.
No other injuries have been reported. Police said there were not believed to be any suspicious circumstances surrounding his death.
Greater Manchester Fire and Rescue Service said three fire engines from Agecroft, Blackley and Heywood were called shortly before 6.50pm to an incident involving a domestic building on Rectory Green.
Firefighters worked alongside police to make the area safe.
Police enquiries remain ongoing.
