Wayne, aged 45, was last seen at the Manchester Royal Infirmary at around 8am on August 21.
He is described as black, around 5ft 9ins tall and of a medium build and was last seen wearing a burgundy t-shirt, black tracksuit bottoms, a black Berghaus gillet and black Nike TN shoes.
Wayne has a scar on the bridge of his nose and on his left wrist and a tattoo of a black panther on his right arm.
He requires medication which he has not picked up and may become ill if he doesn't take it.
Officers are becoming increasingly concerned about Wayne and want to make sure he is safe and well.
Anyone with information about Wayne's whereabouts should contact police on 0161 856 0765.
