Officers were called to the junction of Stockfield Road and Peel Street at approximately 6.35pm last night to reports of a road traffic collision between two vehicles.
A passenger of one of the vehicles sustained serious injuries.
Colleagues from North West ambulance Service took the man to hospital and he is described as being stable following surgery.
A man has since been arrested on suspicion of causing serious injury by dangerous driving.
He remains in custody for questioning.
GMP are now appealing for witnesses to the incident and for anyone who may have any dashcam, doorbell or CCTV footage to come forward to help with the investigation.
Anyone with any information is asked to contact 101, quoting log number 3290-280623.
Information can also be passed through the independent charity, Crimestoppers, on 0800 555 111, or via the Live Chat function on the website, www.gmp.police.uk
