The bus had been travelling on Moston Lane East, before colliding with the pedestrian.
The boy sustained serious injuries and remains in hospital at this time.
These injuries are described as life-changing, but are not believed to be life-threatening.
No injuries were reported by anyone on the bus.
Police would appeal for any witnesses, who have not yet spoken to officers, to contact GMP.
Anyone with dash cam or CCTV footage is also encouraged to come forward.
You can do this by calling GMP's Serious Collision Investigation Unit on 0161 856 4741 or 101, quoting log 2486 of 12/10/24.
